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目的:检测喉鳞状细胞癌细胞中p-STAT3及p53蛋白的表达,探讨它们的临床意义及其相关性。方法:采用免疫组织化学技术,检测p-STAT3及p53蛋白在60例喉鳞状细胞癌和32例取自喉全(或近全)切除者癌旁(>2.0cm)处正常喉黏膜组织中的表达,应用显微图像分析系统测定阳性表达的平均光密度值,并进行统计分析。结果:在喉鳞状细胞癌组织中存在p-STAT3及p53蛋白的高表达;p-STAT3和p53蛋白的表达与喉鳞状细胞癌的临床分期、淋巴结转移有关(P<0.05);在喉鳞状细胞癌组织中p-STAT3和p53蛋白的表达存在正相关关系,相关系数r=0.655 8(P<0.01)。结论:p-STAT3和p53蛋白的表达与喉鳞状细胞癌的发生、发展和转移等生物学行为有关,两者的表达呈正相关关系。
Objective: To detect the expression of p-STAT3 and p53 protein in laryngeal squamous cell carcinoma (LSCC) and to investigate their clinical significance and their correlation. Methods: Immunohistochemical technique was used to detect the expression of p-STAT3 and p53 protein in 60 cases of laryngeal squamous cell carcinoma and 32 cases of normal laryngeal mucosa adjacent to carcinoma (> 2.0 cm) The average optical density of positive expression was determined by microscopic image analysis system and statistical analysis was performed. Results: The expression of p-STAT3 and p53 protein in laryngeal squamous cell carcinoma was high. The expression of p-STAT3 and p53 protein was correlated with the clinical stages and lymph node metastasis of laryngeal squamous cell carcinoma (P <0.05) There was a positive correlation between the expression of p-STAT3 and p53 protein in squamous cell carcinoma, the correlation coefficient was 0.655 8 (P <0.01). CONCLUSION: The expressions of p-STAT3 and p53 are correlated with the biological behavior of laryngeal squamous cell carcinoma, such as the occurrence, development and metastasis. There is a positive correlation between them.