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血液凝固系统和血小板系统在慢性肾小球肾炎的致病机理中的作用已受到瞩目。作者概述抗凝和抗血小板药物的用法,肾组织学所见及其临床价值。抗凝疗法为抑制肾小球内的血液凝固和纤维蛋白沉着,解除其对肾小球的损害,可注射肝素5000～20000U/日,调节剂量使Lee-White凝血时间延长到正常值的2～3倍。或口服华法令1～8mg/日,用凝血酶活动度测定试验进行监测,调整剂量使其为20～30％。目前多并用抗血小板药。因易引起出血,主要适用于预后不良的肾损害。目前常用于治疗急性进行性肾小球肾炎、膜性增生性肾小球肾炎,溶血性尿
The role of the blood coagulation system and the platelet system in the pathogenesis of chronic glomerulonephritis has drawn attention. The authors outline the use of anticoagulant and antiplatelet drugs, renal histology findings and their clinical value. Anticoagulant therapy to inhibit glomerular blood coagulation and fibrin deposition, the lifting of the glomerular damage, injection of heparin 5000 ~ 20000U / day, adjusting the dose to Lee-White clotting time extended to normal 2 ~ 3 times. Or oral warfarin 1 ~ 8mg / day, with thrombin activity measurement test monitoring, adjust the dose to make it 20 ~ 30%. At present and more antiplatelet drugs. Due to easy to cause bleeding, mainly for poor prognosis of renal damage. Currently used in the treatment of acute progressive glomerulonephritis, membranoproliferative glomerulonephritis, hemolytic urine