【摘 要】
：
A nitrone-modified 1,8-naphthalimide was designed as a novel bioorthogonal-activated turn-on probe based on strain-promoted al-kyne-nitrone cycloaddition (SPANC).The bioorthogonal cycloadducts were subsequently transformed into fluorescent rearrange-ment
【机 构】
：
State Key Laboratory of Bioactive Substances and Function of Natural Medicine,Beijing Key Laboratory
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A nitrone-modified 1,8-naphthalimide was designed as a novel bioorthogonal-activated turn-on probe based on strain-promoted al-kyne-nitrone cycloaddition (SPANC).The bioorthogonal cycloadducts were subsequently transformed into fluorescent rearrange-ment products by photo-acceleration,which exhibited significant fluorescence enhancement,large stokes shift,and high fluores-cence quantum yield.DFT calculations were performed to elucidate the fluorescence OFF-ON mechanism.This fluorogenic strategy was successfully applied to labeling of proteins and visualizing mitochondria in live cells in real time.
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