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目的 探讨干扰素α -1b早期治疗肾综合征出血热的疗效。方法 将 12 0例肾综合征出血热患者采用随机双盲对照的方法分成两组 ,干扰素组 6 0例 ,男性 42例 ,女性 18例 ,平均 32岁 ,在综合治疗的基础上入院后即给予应用干扰素α -1b 3MU ,肌肉注射 ,1次 /d ,连用 5d。对照组 6 0例 ,男性 40例 ,女性 2 0例 ,平均 31岁 ,仅用综合治疗 (止血、扩容、利尿、抗休克、支持治疗 )。结果 干扰素组在缩短热程、体征消失时间、提高越期率、肾功能及血小板复常时间方面明显优于对照组。结论 应用干扰素α -1b早期治疗肾综合征出血热疗效明显 ,不良反应轻微
Objective To investigate the efficacy of interferon α-1b in the early treatment of hemorrhagic fever with renal syndrome. Methods One hundred and twenty cases of hemorrhagic fever with renal syndrome were divided into two groups according to a randomized, double-blind control. Interferon group 60 cases, male 42 cases, female 18 cases, average 32 years old. On the basis of comprehensive treatment, Administration of interferon alpha-1b 3MU was given intramuscularly, once daily for 5 days. Control group 60 cases, 40 males and 20 females, average 31 years old, only the combined treatment (bleeding, dilatation, diuretic, anti-shock, supportive treatment). Results The interferon group was significantly better than the control group in shortening the heat stroke, the disappearance of signs, improving the overdue rate, renal function and platelet remission time. Conclusion Early treatment of hemorrhagic fever with renal syndrome with interferon α-1b has obvious curative effect with mild side effects