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目的：检测慢性阻塞性肺疾病（COPD）急性加重期患者脂联素和炎症因子，并研究其临床意义。方法：检测COPD急性加重期患者（AECOPD组）和正常人（CON组）脂联素、hs-CRP、TNF-α、IL-6和IL-8并比较其差异，分析AECOPD组患者脂联素、hs-CRP、TNF-α、IL-6和IL-8与APACHEⅡ评分的相关性。结果：AECOPD患者脂联素显著低于CON组，hs-CRP、TNF-α、IL-6和IL-8均显著高于CON组，差异均具有统计学意义（均P<0.001）。AECOPD组患者脂联素与APACHEⅡ评分呈负相关（rs<0， P0，P<0.05）。结论：COPD急性加重期患者脂联素显著降低，hs-CRP、TNF-α、IL-6和IL-8显著升高，可作为COPD急性加重期病情评估的标志物。“,”Objective Detection chronic obstructive pulmonary disease (COPD) patients with acute aggravating period of adiponectin and inflammatory factor, and study its clinical significance.Methods Detection COPD patients with acute exacerbation period (AECOPD) and normal group (CON) adiponectin, hs CRP, TNF alpha, IL - 6 and IL - 8, and compares their differences, Analysis of the correlation.Results Adiponectin AECOPD patients was significantly lower than CON group. The hs CRP, TNF alpha, IL - 6 and IL - 8, significantly higher than that of CON group, difference has statistical significance (P < 0.001).Conclusions COPD patients with acute aggravating period of adiponectin decreased significantly, the hs CRP, TNF alpha, IL - 6 and IL - 8, a significant rise, can be used as COPD acute aggravating period of condition evaluation markers.