论文部分内容阅读
[目的]研究survivin、丝氨酸/苏氨酸激酶15(serine threonine kinase15,STK15)在非小细胞肺癌中的表达及其意义。[方法]采用免疫组化法检测86例非小细胞肺癌和20例肺良性病变组织中survivin、STK15的表达。[结果]Survivin、STK15在非小细胞肺癌组织中阳性表达率分别为59.3%(51/86)、72.1%(62/86),显著高于肺良性病变组织(P<0.05)。Survivin和STK15表达均与肺癌患者的分化程度、TNM分期密切相关(P<0.05)。[结论]Survivin、STK15表达与非小细胞肺癌的临床病理学特征密切相关,两者的联合检测将有助于评估肺癌患者的恶性程度和预后。
[Objective] To investigate the expression of survivin and serine threonine kinase 15 (STK15) in non-small cell lung cancer and its significance. [Method] The expressions of survivin and STK15 in 86 non-small cell lung cancer tissues and 20 benign lung disease tissues were detected by immunohistochemistry. [Results] The positive rates of Survivin and STK15 in non-small cell lung cancer tissues were 59.3% (51/86) and 72.1% (62/86), respectively, which were significantly higher than those in benign lung tissues (P <0.05). The expressions of Survivin and STK15 were closely related to the differentiation degree and TNM stage of lung cancer (P <0.05). [Conclusion] The expression of Survivin and STK15 is closely related to the clinicopathological features of non-small cell lung cancer. The combined detection of Survivin and STK15 will be helpful to evaluate the malignancy and prognosis of patients with lung cancer.