药物与蛋白结合的现象被认识已有半个多世纪,但其在药理学上意义和在临床上引起注意还是近廿年的事。药物与蛋白结合实际上是药物分子与生物大分子之间相互作用的结果,它是分子药理学研究的重要课题之一。尤其是药物与血浆蛋白结合会影响到药物的生物学活性,即影响作用强度和时间的长短,进而对药物的吸收、分布、排泄及其他方面产生重要作用,所以也是药物代谢动力学和临床药理学的一个重要组成部分。故引起了人们愈来愈多的注意和研究。本文着重介绍药物与血浆蛋白结合的一 The phenomenon of drug-protein binding has been recognized for more than half a century, but it is still pharmacologically and clinically interesting for nearly two decades. Drug-protein binding is actually the result of the interaction between drug molecules and biological macromolecules, which is one of the important topics in molecular pharmacology. In particular, the binding of drugs to plasma proteins can affect the biological activity of the drug, ie, the intensity and duration of the effect, which in turn has an important effect on the absorption, distribution, excretion and other aspects of the drug and is therefore also pharmacokinetic and clinical pharmacological An important part of learning. It has aroused more and more people’s attention and research. This article focuses on one of the drugs and plasma protein binding