小儿隐球菌病近年发病有上升趋势。为提高对本病的认识，降低误诊率，我们对４例小儿全身性隐球菌病进行了总结和分析。发现：发病年龄较以往资料偏小，因累及脏器的异同，起病方式及临床表现呈多样化，鉴别诊断十分重要。提高对本病的警惕性，对可疑病人反复多次墨汁染色找隐球菌，是降低误诊率的有效措施。 Pediatric cryptococcosis in recent years the incidence of an upward trend. In order to raise awareness of this disease and reduce the rate of misdiagnosis, we summarized and analyzed 4 pediatric systemic cryptococcosis. Found: age of onset than the previous data is too small, due to the similarities and differences involving organs, onset and clinical manifestations were diversified, differential diagnosis is very important. Improve the vigilance of the disease, repeatedly suspected ink stain to find Cryptococcus, is an effective measure to reduce the rate of misdiagnosis.