目的:探讨氟哌噻吨美利曲辛与认知行为疗法在联合治疗卒中后抑郁方面的临床疗效。方法:选取68例卒中后抑郁患者随机分成两组,每组34例,两组均行常规疗法并服用氟哌噻吨美利曲辛片,观察组在此基础上联合认知行为疗法,观察两组治疗效果。结果:观察组治疗2-4周后HAMD评分明显低于对照组,且治疗总有效率显著高于对照组,p<0.05,有统计学意义。结论:氟哌噻吨美利曲辛联合认知行为疗法治疗卒中后抑郁效果显著,值得在临床上推广。 Objective: To investigate the clinical efficacy of flupenthixol and melitracen in combination with cognitive behavioral therapy in the treatment of post-stroke depression. Methods: Sixty-eight patients with post-stroke depression were randomly divided into two groups, 34 in each. Both groups underwent routine therapy and took flupentixol and melitracen tablets. On the basis of this observation, the observation group was treated with cognitive behavioral therapy Two groups of treatment. Results: The HAMD score of the observation group after 2-4 weeks of treatment was significantly lower than that of the control group, and the total effective rate was significantly higher than that of the control group, p <0.05, with statistical significance. Conclusion: Flupenthixol combined with melitracen in combination with cognitive behavioral therapy for post-stroke depression is effective and worthy of clinical promotion.