本文报告2例因长期不必要地服用了利尿剂所致的水肿。2例均系所谓“特发性浮肿”病患者,在服用利尿剂的过程中水肿仍渐加重,最后停用了利尿剂,水肿终见消退。例1:22岁女性于1970年6月因发现两踝轻度水肿(心、肾无疾病)给予速尿40毫克每日2次和钾盐片治疗。但两踝和面部的水肿反而加重。于1971年起加用氯塞酮,疗效仍不明显反而导致了低血钾症和一次痛风发作。于1972年停服氯塞酮而将速尿的剂量增加为每天160毫克,共达18个月之久,但因症状仍无改善而住院。入院时即停用速尿,病人的膳食内含钠135毫克当量,钾47毫克当量。于停药后5天,患者的体重增加了2.3公斤,尿钠排出量显著减少,但到第6天尿钠排泄增加,乃将饮食内钠量降至10毫当量,在8天内体重减轻4.9公斤,停药后一个月体重仍继续减轻,后给病人正常饮食,这时病人体重又增加6公斤,但比在服用利尿剂前为轻。在正常饮食和不用药物治疗的情况下一年不再发生水肿。例2:45岁妇女,1971年行胆囊切除术后出现少尿,而用速尿治疗,但患者手指和面部、两踝发生间 This article reports 2 cases of edema due to long-term unnecessary diuretic. 2 cases were the so-called “idiopathic edema” patients, diuretics in the process of edema is still getting heavier, and finally deactivated diuretics, edema finally subsided. Example 1: 22-year-old woman was given furosemide 40 mg twice daily and potassium salt tablets for her two ankle mild edema (heart and kidney disease) in June 1970. However, both ankles and facial edema but increased. In 1971 with the use of cloxacone, the effect is still not obvious but led to hypokalemia and a gout attack. Stop taking cloxaprid in 1972 and increase the dose of furosemide to 160 mg daily for a total of 18 months, but were hospitalized for symptoms that did not improve. Fasting urine was deactivated on admission, and the patient’s diet contained 135 mg of sodium and 47 mg of potassium. Five days after discontinuation, the patient gained 2.3 kg body weight and had a significant reduction in urinary sodium excretion, but increased urinary sodium excretion on day 6, reducing the amount of sodium in the diet to 10 meq and weight loss within 8 days 4.9 Kg, one month after discontinuation of weight still continue to reduce weight, after giving the patient a normal diet, when the patient’s weight increased by 6 kg, but before taking diuretics was lighter. Edema does not recur in one year in the normal diet and without medication. Example 2: 45-year-old woman, oligochium after cholecystectomy in 1971, but with furosemide treatment, but the patient’s fingers and face, between the ankle occurred