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本文用N-(5-氟尿嘧啶乙酰)谷氨酸双对硝基苯酯与一系列α、ω-多次甲基二胺缩聚制备了6种侧链含5-氟尿嘧啶的聚酰胺。通过元素分析、核磁共振谱、红外光谱和紫外光谱对单体和聚合物的结构进行了鉴定。经初步抗动物肿瘤试验,聚α-(5-氟尿嘧啶乙酰胺基)戊二酰乙二胺对艾氏腹水癌的抑制率为43.0％。
In this paper, six polyamides containing 5-fluorouracil were synthesized by polycondensation of bis (p-nitrophenyl) glutamate with N- (5-fluorouracil) glutamic acid and a series of α, ω- The structures of monomers and polymers were identified by elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectroscopy and ultraviolet spectroscopy. The preliminary anti-tumor animal experiments, poly α- (5-fluorouracil acetamido) glutaryl ethylene diamine Echlisis ascites cancer inhibition rate was 43.0%.