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目前，无托槽隐形矫治被越来越多地应用于成人正畸治疗及牙周病患者的正畸治疗中。对于轻中度牙周病患者，无托槽隐形矫治可获得较好的矫治效果；对于重度牙周病患者，无托槽隐形矫治仍存在风险，需严格把控适应证。明确牙周病患者的正畸治疗目标，严格控制牙齿移动范围，多学科联合治疗疑难病例，是正畸临床需关注的内容。牙周病患者无托槽隐形矫治时需确定可行的矫治目标位，根据牙周情况进行合理分步、设置适当的附件以及设计减小牙龈刺激的矫治器边缘。本文针对无托槽隐形矫治在牙周病患者正畸治疗中的应用领域，从适应证选择、矫治目标、矫治器设计、多学科联合治疗中的作用以及矫治器对牙周健康的影响等方面进行探讨。“,”Clear aligner is a kind of removable orthodontic appliance, which designed and manufactured using digital technology. It is more and more widely used in adults and patients with periodontal disease. Clear aligner treatment in patients with moderate and mild periodontal diseases can achieve good result. Meanwhile, there are still risks in the clear aligner treatment in patients with severe periodontal diseases, so it is necessary to strictly control the indications. Multidisciplinary treatment of complex periodontal disease is important before the start of orthodontics. The objective of orthodontic treatment in patients with periodontal disease should be made clear and the range of tooth movement must be strictly controlled. In the application of the clear aligner, the feasible target position of clear aligner should be designed. According to patient′s periodontal condition, staging should be designed and the reasonable attachment should be set. The shape of the aligner should be designed to reduce the gingival stimulation. Clear aligner treatment could play an important role in multidisciplinary treatment, and improve the overall effect in patients with periodontal disease. The application of clear aligner in the treatment of periodontal diseases was discussed in various aspects, providing a reference for rational clinical use.