The research studied the influences of high temperature, high pressure, high humidity, noise and other harmful factors in mining conditions on the people health and safety, and investigated the impacts of confined environmental on human physiology factors, including temperature, humidity, noise, pressure,toxic and harmful gases in terms of environmental characteristics in underground mines and an artificial intelligence system for simulation of the environment in a confined space of deep mines. Our results show that the systolic pressure, diastolic pressure, mean pressure, heart rate, respiratory rate, typing test speed and memory level percentage are negatively correlated with temperature value, and positively correlated with humidity value; the human temperature and weight are positively correlated with temperature value, and negatively correlated with humidity value. This research lays the foundation for the study of interaction between the deep confined space environment and safety behavior. The research studied the influences of high temperature, high pressure, high humidity, noise and other harmful factors in mining conditions on the people health and safety, and investigated the impacts of confined environmental on human physiology factors, including temperature, humidity, noise, pressure , toxic and harmful gases in terms of environmental characteristics in underground mines and an artificial intelligence system for simulation of the environment in a confined space of deep mines. Our results show that the systolic pressure, diastolic pressure, mean pressure, heart rate, respiratory rate , typing test speed and memory level percentage are negatively correlated with temperature value, and correlated positively with humidity value; the human temperature and weight are positively correlated with temperature value, and negatively correlated with humidity value. This research lays the foundation for the study of interaction between the deep confined space environment and safety behavior.