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目的以穿心莲内酯微乳为对象,探讨微乳制剂的吸收机理及影响吸收的因素。方法采用大鼠原位灌注实验法,探讨载体抑制剂、能量抑制剂、P-糖蛋白抑制剂对穿心莲内酯微乳在大鼠小肠内吸收行为的影响。结果穿心莲内酯微乳在小肠的吸收需要载体;受到P-糖蛋白外排作用的影响;可能不耗能。结论微乳制剂在小肠中可能存在被动转运和淋巴吸收2种吸收机理。
Objective To investigate the mechanism of absorption of micro and microemulsion and the factors affecting the absorption of andrographolide microemulsion. Methods The rat in situ perfusion experiment was used to investigate the effects of inhibitors, energy inhibitors and P-glycoprotein inhibitors on the absorption of andrographolide microemulsion in rat small intestine. Results The andrographolide microemulsion requires a carrier for absorption in the small intestine; is affected by the efflux of P-glycoprotein; it may not consume energy. Conclusion There may be two kinds of absorption mechanisms of passive transport and lymphatic absorption in the small intestine of microemulsion.