论文部分内容阅读
鼻腔给药是一种很有前途的给药途径,可避免首过效应及胃肠道分解,但有时需要加入吸收促进剂才能达到较高的生物利用度.常用的吸收促进剂胆酸盐因其对鼻粘膜的刺激性而限制了它的应用.本文以酚红为模型药物,比较了6种不同类的表面活性剂对鼻腔吸收的影响.这6种表面活性剂为:胆酸盐类——脱氧牛磺胆酸钠(TDC)、脱氧甘氨酸钠(GDC)和脱氧胆酸钠(DC);脂类——聚氧乙基代蓖麻油(CEL);
Nasal administration is a promising route of administration that avoids first pass and gastrointestinal breakdown, but sometimes requires the addition of absorption enhancers to achieve high bioavailability. The commonly used absorption enhancer, cholate Its irritation to the nasal mucosa has limited its application.In this paper, phenol red as a model drug, compared six different types of surfactants on nasal absorption.The six surfactants are: bile salts - sodium deoxy taurocholate (TDC), sodium deoxyglycinate (GDC) and sodium deoxycholate (DC); lipids - polyoxyethyl castor oil (CEL);