目前耐多种药物的伤寒沙门菌(伤寒杆菌)的发生率正迅速增多,尤其是在东南亚和印度次大陆。虽然英国曾报道出现了耐—环丙沙星的菌株,但该药仍是治疗伤寒的有效药物。1997年中亚的塔吉克斯坦流行伤寒,作者在该国检出了耐—环丙沙星的伤寒杆菌株,这是耐—环丙沙星的菌株导致伤寒流行的首次报道。 The current incidence of multi-drug resistant Salmonella typhi (Salmonella typhi) is rapidly increasing, especially in Southeast Asia and the Indian subcontinent. Although a strain of resistant-ciprofloxacin has been reported in the UK, the drug is still a potent drug for the treatment of typhoid fever. Epidemic typhoid fever was reported in Tajikistan in Central Asia in 1997, where the authors detected a strain of Salmonella typhimurium resistant to ciprofloxacin, the first report of a strain resistant to ciprofloxacin leading to a typhoid epidemic.