1,3-二羰基化合物与芳香族邻二胺作用,生成一类含二氮原子的七元杂环,即1,5-苯骈二氮环庚三烯[1,5-benzodiazepine)类化合物。第一个这类化合物,在一九○七年即由Thiele等用1,3-酮、邻苯二胺与酸作用而制得。晚近的研究表明,这类化合物也可由芳香邻二胺与与α,β-不饱和醛或酮;α,β-不饱和酸或β-卤代酸;酮酸酯以及硝基丙二醛等反应而制得。 The 1,3-dicarbonyl compound interacts with aromatic vicinal diamine to form a kind of nitrogen atom containing seven-membered heterocyclic ring, namely 1,5-benzodiazepine . The first of these compounds was prepared in 1907 by Thiele et al. Using 1,3-keto-o-phenylenediamine and acid. Recent studies have shown that these compounds can also be made from aromatic o-diamines with α, β-unsaturated aldehydes or ketones; α, β-unsaturated acids or β-halo acids; keto esters and nitropropanals Reaction and prepared.