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目的探讨糖尿病患者腰围身高比值(WHtR)与2型糖尿病肾病的相关性。方法选择426例2型糖尿病患者,根据有无并发糖尿病肾病分为糖尿病肾病组(DN)103例和非糖尿病肾病组(NDN)323例。比较两组2型糖尿病患者的血压、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白及WHtR。logistic回归分析WHtR与糖尿病肾病的相关性。结果 DN组患者病程、收缩压、TG、WHtR分别为(8.7±7.6)年、(140±20)mmHg、(2.59±2.11)mmol/L、0.58±0.06,较NDN组[分别为(6.6±6.2)年、(131±17)mmHg、(2.01±1.69)mmol/L、0.55±0.06]明显增高,差异均有统计学意义(P<0.05,P<0.01),调整了性别、年龄、糖尿病病程、血压、血脂谱、糖化血红蛋白后,WHtR与糖尿病肾病明显正相关(OR=594.899,95%CI:8.731~40 534.869)。结论 WHtR是2型糖尿病肾病的独立危险因素,积极防治肥胖可能有助于糖尿病肾病的防治。
Objective To investigate the relationship between waist circumference ratio (WHtR) and type 2 diabetic nephropathy in diabetic patients. Methods A total of 426 patients with type 2 diabetes mellitus (T2DM) were divided into 103 diabetic nephropathy patients (DN) and 323 non-diabetic nephropathy patients (NDNs) according to the presence or absence of diabetic nephropathy. Blood pressure, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin and WHtR were compared between two groups of type 2 diabetic patients. Logistic regression analysis of the correlation between WHtR and diabetic nephropathy. Results The course of disease, systolic blood pressure, TG and WHtR were (8.7 ± 7.6) years, (140 ± 20) mmHg and (2.59 ± 2.11) mmol / L and 0.58 ± 0.06 in DN group (131 ± 17) mmHg, (2.01 ± 1.69) mmol / L, 0.55 ± 0.06] in control group (P> 0.05), and the difference was statistically significant WHtR was significantly positively correlated with diabetic nephropathy (OR = 594.899, 95% CI: 8.731 ~ 40 534.869) after the course of disease, blood pressure, blood lipid profile and glycosylated hemoglobin. Conclusion WHtR is an independent risk factor for type 2 diabetic nephropathy, and prevention and treatment of obesity may be helpful for the prevention and treatment of diabetic nephropathy.