败血症,特别是腹腔内感染肠道内感染为其原因时,由于肠壁的抵抗力很弱,肠道内革兰氏阴性杆菌细胞壁成分的内毒素大量进入门静脉血中,就会引起肝损害或肝细胞功能变化。有意义的是在临床水平上出现于血中的内毒素浓度,对肝实质细胞几乎没有影响,而是它被单核细胞吞噬后,通过其免疫学机制才对肝细胞产生影响。由于肝是来自肠道病原的第一个靶器官,同时又是主要的防御器官,所以这种平衡当侵袭占优势时,症状就加速恶化,往往出现肝功能不全。内毒素所致的肝变化之所以难以搞清其病理,原因在于生物学活性的多样性。这是由于补体、细胞激肽、花生四烯酸代谢产物、自由基等因素复杂地交织在 Sepsis, especially intraperitoneal infection of the gut infection for its causes, due to weak intestinal wall resistance, intestinal Gram-negative bacillus cell wall composition of endotoxin into the portal vein in large numbers, it will cause liver damage or liver cells Function changes. What is significant is that the level of endotoxin that appears in the blood at the clinical level has little effect on the hepatic parenchymal cells but rather it affects the hepatocytes only through its immunological mechanism after it is phagocytosed by monocytes. Since the liver is the first target organ from the gut pathogen and at the same time the major defensive organ, this balance accelerates the worsening of symptoms as predispositions predominate, often with hepatic insufficiency. The reason why endotoxin-induced liver changes are difficult to understand is due to the diversity of biological activities. This is due to complex factors such as complement, cytokinin, arachidonic acid metabolites, free radicals and other interwoven