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目的研究伴 t( 8;2 1)染色体易位的急性髓细胞性白血病 ( AML)预后及影响预后的相关因素。方法对 44例伴 t( 8;2 1)易位 M2亚型与同期无 t( 8;2 1)易位的 M2 亚型的临床表现、血液学异常及完全缓解率进行比较。结果两组在外周血象骨髓象及完全缓解率、生存期无明显差异。结论伴 t( 8;2 1)易位的 M2 亚型并不比其他类型 AML具有优越性 ,能否通过大剂量阿糖胞苷或组蛋白去乙酰化酶抑制剂及糖皮质激素治疗 ,可能有助于提高疗效
Objective To investigate the prognosis of acute myeloid leukemia (AML) associated with t (8; 2 1) chromosomal translocation and the related prognostic factors. Methods The clinical manifestations, hematological abnormalities and complete remission rates of 44 M2 subtypes with t (8; 2 1) translocation and those with no t (8; 2 1) translocations during the same period were compared. Results There was no significant difference in the survival rate between the two groups in peripheral blood as the bone marrow and complete remission rate. Conclusions The M2 subtype with t (8; 2 1) translocation is superior to other AMLs in that it can be treated with high doses of cytarabine or histone deacetylase inhibitors and glucocorticoids and may have Help to improve the curative effect