目的:评价辅助生殖技术(ART)助孕后多胎妊娠早孕期减胎术的安全性及必要性。方法:回顾性分析91例多胎妊娠B超引导下经阴道选择性减胎患者的临床资料,统计其早期流产率、晚期流产率,并将减胎后的患者分为单胎妊娠组及双胎妊娠组,统计各组早产率、早产孕周、早产平均体质量及足月低体质量儿出生率,并与同期施行ART助孕的单胎妊娠及未行减胎的双胎妊娠4 623例进行比较分析。结果:减胎组早期流产率为2.20%,明显优于同期妊娠的早期流产率(10.96%),组间有统计学差异。减胎后的单胎妊娠组早产率、早期流产率及晚期流产率均优于未行减胎的双胎妊娠组。结论:早孕期施行B超引导下经阴道选择性减胎术是安全的,且可有效减少多胎妊娠发生,改善其不良妊娠结局。 Objective: To evaluate the safety and necessity of assisted reproductive technology (ART) in reducing labor during the first trimester of pregnancy with multiple pregnancies. Methods: The clinical data of 91 cases of transvaginal selective abortion guided by B-ultrasound guided by multiple pregnancy were retrospectively analyzed. The rates of early miscarriage and late abortion were calculated. The patients after abortion were divided into singleton pregnancy group and twin pregnancy group Pregnancy group, the rate of preterm birth in each group, gestational age at premature delivery, average body weight of preterm birth and full-term low birth weight children birth rate, with the same period of ART assisted pregnancy and unmarried twin pregnancies without pregnancy twin pregnancy 6243 comparative analysis. Results: The abortion rate of early abortion group was 2.20%, which was significantly better than the rate of early miscarriage (10.96%) in the same period of pregnancy, with statistical difference between the two groups. Premature birth rate, early miscarriage rate and late miscarriage rate in singleton pregnancy group after abortion were better than those in non-abortion twin pregnancy group. CONCLUSION: Transvaginal selective abortion guided by B-ultrasound in early pregnancy is safe and effective in reducing the incidence of multiple pregnancy and improving its adverse pregnancy outcome.