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流行病学调查显示:糖尿病患者比正常人得帕金森病的几率要高83%以上。尤其早期糖尿病,在没有其他并发症的时候,其患帕金森的几率是正常人的7倍。而在帕金森病的晚期,有一个特征就是黑质纹状体通路的多巴胺含量减少。本研究以SH-SY5Y神经母细胞瘤作为多巴胺能神经元的细胞模型,首先用200mmol/L葡萄糖处理SH-SY5Y模型细胞48小时,用HPLC-ECD检测细胞内多巴胺的含量,发现SH-SY5Y细胞在200mmol/L的葡萄糖处理48小时后,细胞内的多巴胺含量降低。本研究提示我们,在长期的高血糖条件下,细胞内会产生类似帕金森病的多巴胺减少的效应。
Epidemiological survey shows: diabetic patients than normal people have a higher probability of Parkinson’s disease more than 83%. In particular, early-stage diabetes mellitus is seven times more likely to develop Parkinson’s without any other complication. A characteristic feature of late Parkinson’s disease is the reduced dopamine content of the nigrostriatal pathway. In this study, SH-SY5Y neuroblastoma cells as a model of dopaminergic neurons, first with 200mmol / L glucose treatment of SH-SY5Y model cells for 48 hours, using HPLC-ECD detection of intracellular dopamine content found SH-SY5Y cells After 48 hours of treatment with 200 mmol / L glucose, the intracellular dopamine content was reduced. This study suggests that under long-term hyperglycemic conditions, there is an intracellular similar effect of reducing dopamine in Parkinson’s disease.