目的：探讨藻酸双酯钠（ＰＳＳ）对肾病综合征（ＮＳ）的疗效及机理。方法：用阿霉素（ＡＤＲ）静脉注射建立大鼠肾病模型，观察大鼠尿蛋白排泄量，测定有关生化指标和凝血功能，并以ｐｏｌｙｅｔｈｙｌｅｎｅｍｉｎｅ（ＰＥＩ）为探针检查肾病大鼠ＧＢＭ阴离子位点，结合组织学及形态学改变，进行远期疗效评估。结果：ＰＳＳ可显著降低肾病大鼠尿蛋白的排泄，纠正脂质代谢紊乱，延缓ＭＣＮＳ发展至ＦＳＧＳ的进程，且对肾小球电荷屏障具有保护作用。结论：胃饲ＰＳＳ对阿霉素肾病大鼠具有明显的保护作用，为临床应用提供了理论依据 Objective: To investigate the efficacy and mechanism of sodium alginate (PSS) on nephrotic syndrome (NS). Methods: The rat model of nephropathy was established by intravenous injection of adriamycin (ADR). Urinary protein excretion was measured. The biochemical indexes and coagulation function were determined. Polyethylene glycol (PEI) was used as a probe to detect GBM anion sites , Combined with histological and morphological changes, long-term efficacy evaluation. Results: PSS could significantly reduce excretion of urinary protein in rats with nephrotic syndrome, correct the disturbance of lipid metabolism, delay the progression of MCNS to FSGS, and protect the glomerular charge barrier. Conclusion: Stomach feeding PSS has a significant protective effect on adriamycin-induced nephropathy in rats, providing a theoretical basis for clinical application