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目的:探讨压力调节容积控制通气治疗慢性阻塞性肺疾病合并肺性脑病的临床应用价值。方法:对24例慢性阻塞性肺疾病合并肺性脑病患者的临床资料进行回顾性分析。结果:以压力调节容积控制通气的治疗组在通气1小时、12小时后,动脉血氧分压和动脉血氧饱和度与未通气时的差值均较容积控制通气的治疗组明显升高(P均<0.01),动脉血二氧化碳分压的差值降低(P<0.05),动脉血氧饱和度的差值明显降低(P<0.05);通气1小时、12小时后压力调节容积控制通气治疗组的气道峰压(PIP)、平均吸气流速VT/Tinflate明显下降(p<0.01),吸气峰流速(PTF)、呼气峰流速(PEF)出现显著增高(P<0.01)。结论:压力调节容积控制通气是一新型通气模式,在临床应用中,对降低气道压力、确保肺泡通气方面有着独特的优势,有较好的应用前景。
Objective: To investigate the clinical value of pressure-controlled volume controlled ventilation in the treatment of chronic obstructive pulmonary disease with pulmonary encephalopathy. Methods: The clinical data of 24 patients with chronic obstructive pulmonary disease complicated with pulmonary encephalopathy were analyzed retrospectively. Results: After 1 hour and 12 hours of ventilation, the difference between arterial partial pressure of oxygen and arterial oxygen saturation and non-ventilated group were significantly higher than those of volume-controlled ventilation group P <0.01). The difference of partial pressure of arterial carbon dioxide was decreased (P <0.05) and the difference of arterial oxygen saturation was significantly decreased (P <0.05). After ventilation for 1 hour and 12 hours, The peak airway pressure (PIP), VT / Tinflate (P <0.01), and peak expiratory flow (PTF) and expiratory peak flow velocity (PEF) of the rats in the group were significantly decreased (P <0.01). CONCLUSION: Pressure-controlled volume-controlled ventilation is a new ventilation mode. It has unique advantages in reducing airway pressure and ensuring alveolar ventilation in clinical application and has a good application prospect.