细胞间的信息传递在细胞发育分化过程中扮演着重要角色。Notch信号通路作为一种进化上相对保守的细胞相互作用机制,维持着细胞增殖、分化、凋亡之间的平衡,其能够扩大并固化相邻细胞之间的分子差异,对细胞分化命运起决定性作用。本文综述了Notch蛋白的基本结构、Notch信号通路的激活方式、其主要相关分子以及Notch信号通路在肝癌中的作用。 Intercellular communication plays an important role in cell development and differentiation. Notch signaling pathway is a kind of evolutionarily relatively conserved cell interaction mechanism, which maintains the balance between cell proliferation, differentiation, and apoptosis. It can expand and solidify the molecular differences between adjacent cells, which is decisive for the differentiation and fate of cells. effect. This article reviews the basic structure of Notch protein, the activation of Notch signaling pathway, its main related molecules, and the role of Notch signaling pathway in hepatocellular carcinoma.