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本文对60例老年缺血性心脑疾患伴高粘血症患者用双盲、随机、交叉对照法进行治疗前后疗效观察。比较东菱克栓酶和706代血浆对血液流变学多项参数的疗效．发现东菱克栓酶一疗程后疗效明显优于706代血浆，交叉用药后，仍可使706代血浆治疗组各项参数进一步下降，其中对体外血栓形成的长度、干重、湿重、疗效十分显著．其主要作用机制是它可分解纤维蛋白原，抑制血栓形成，并诱发t－Pt释放，增强t－Pt作用的能力，尚能促进纤维蛋白溶酶的生成，降低纤维蛋白溶酶原活化质抑制因子（PAI）的活性，降低血粘度，抑制红细胞凝集．而706代血浆虽也能使各参数下降，但下降幅度小，范围窄，且有少数患者出现皮肤骚痒等过敏反应．认为东菱克栓酶应作为高粘血症患者的首选药物。
In this paper, 60 elderly patients with ischemic cardiovascular and cerebrovascular disease with hyperviscosity were treated with double-blind, randomized, cross-control study before and after treatment. To compare the curative effect of multiple parameters of hemorheology by using Tongling Kexu enzyme and 706 generations of plasma. It was found that the curative effect was obviously better than that of the 706 generation plasma after the treatment of Tongling Ke thrombin, and the parameters of the 706 generation plasma treatment group could still be further decreased after the crossover treatment, in which the length, dry weight, wet weight and curative effect of thrombosis in vitro Very significant. Its main mechanism is that it can break down fibrinogen, inhibit thrombus formation, and induce the release of t-Pt, enhance the ability of t-Pt, still can promote the formation of plasmin and reduce the inhibition of plasminogen activator Factor (PAI) activity, reduce blood viscosity, inhibition of erythrocyte aggregation. The 706 generation of plasma, although the parameters can also be reduced, but the decline in small, narrow range, and a small number of patients with skin itching and other allergic reactions. It is thought that Clonidine should be the drug of choice for patients with hyperviscosity.