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从3-(1′,3′-二氧戊环-2-基)-5α,10α-环氧-△~(9(11))-雌甾烯-17-酮合成了11β-苯基取代的雌甾化合物。体外筛选表明11β-乙酰苯基取代的化合物(4e～4g)较米非司酮(RU-486)具有较强的孕酮受体竞争结合力和较低的糖皮质激素受体结合力。
Synthesis of 11β-phenyl substitutions from 3- (1 ’, 3’-dioxolan-2-yl) -5α, 10α-epoxy- Δ ~ (9 (11) Of estrogen. In vitro screening demonstrated that 11β-acetophenone-substituted compounds (4e-4g) exhibited stronger progesterone receptor competitive binding and lower glucocorticoid receptor binding than mifepristone (RU-486).