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目的:分析神经节苷脂钠注射液出现聚集性不良反应的影响因素。方法:调阅本院ADR/ADE监测系统内的7份神经节苷脂注射液聚集性不良反应记录及相关病历,对用药人群、使用环节、ADR症状等因素进行调查分析。结果:经质量检验,此次使用的神经节苷脂注射液为合格药品,此次聚集性不良反应表现为抽搐、寒战、发热等过敏样症状。7例聚集性不良反应的发生时间、溶媒选择、药物用量、滴速等因素基本相同,仅在溶媒用量、合并用药方面存在差异。结论:导致聚集性不良反应发生的影响因素很多,难以确定某个具体因素。聚集性ADR一旦发现,应立即停药,及时上报,寻找原因,推动药品质量不断提高和临床用药不断规范。
Objective: To analyze the influencing factors of aggregate adverse reactions in ganglioside sodium injection. Methods: 7 ADR / ADE monitoring system collected in our hospital ADG record of ADR and related medical records, drug use, links, ADR symptoms and other factors were investigated. Results: The quality of testing, the use of ganglioside injection of qualified drugs, the aggregate adverse reactions showed convulsions, chills, fever and other allergic symptoms. The time of onset of ADF, solvent selection, drug dosage, drip rate and other factors were basically the same. There were differences only in the amount of solvent and drug combination. Conclusion: There are many influencing factors for the occurrence of aggregation adverse reactions and it is difficult to determine a specific factor. Aggregated ADR once found, should immediately discontinued, timely reporting, looking for reasons to promote the continuous improvement of drug quality and clinical medication continue to regulate.