(接上期 )3　联二萘酚母体环上的取代3 1　 3位碳上的取代联二萘酚 3位碳上的取代基通常是以两步反应来引入的 :先将保护的联二萘酚与有机锂试剂反应生成金属锂络合物 ,金属锂络合物再与亲电试剂反应。例如 :Cram等通过Mannich中间体〔4 8〕制备了一系列的 3,3’位取代的联二萘 (Continued) Substitutions on the 3-Binaphthol Parent Ring 3 Substitution on the Carbon at the 3-position Carbonyl substituents on the 3-position of the binaphthol are usually introduced in two steps: the protected diphenylene The reaction of phenol and organolithium reagents to form lithium metal complexes, lithium metal complexes with electrophiles and then react. For example, Cram et al prepared a series of 3,3 ’substituted diphenylethanes via Mannich intermediates [48]