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为探讨多脏器功能失常综合征（ＭＯＤＳ）中胰腺炎与细胞因子、炎性介质的关系。检测了８例由严重创伤并发休克或急性重症感染引起的ＭＯＤＳ患者（Ａ组）、５例ＭＯＤＳ并发胰腺炎患者（Ｂ组）和７例急性水肿型胰腺炎患者（Ｃ组）的肿瘤坏死因子（ＴＮＦ）和内皮素（ＥＴ）水平。发现Ａ组ＴＮＦ、ＥＴ水平明显高于Ｃ组（Ｐ＜０．００１）；Ｂ组ＴＮＦ水平明显高于Ａ组（Ｐ＜０．０５）；ＥＴ水平则呈升高趋势，但无显著统计学意义。提示：ＴＮＦ和ＥＴ的释放增多与ＭＯＤＳ的发病有重要意义；ＴＮＦ、ＥＴ释放的进一步增多（尤其是ＴＮＦ）可能导致更多脏器（包括胰腺）功能的损伤乃至衰竭
To investigate the relationship between pancreatitis and cytokines and inflammatory mediators in multiple organ dysfunction syndrome (MODS). 8 patients with MODS (Group A), 5 patients with MODS with pancreatitis (Group B) and 7 patients with acute edematous pancreatitis (Group C) caused by severe trauma complicated with shock or severe acute infection were tested for tumor necrosis factor. (TNF) and Endothelin (ET) levels. The levels of TNF and ET in group A were significantly higher than those in group C (P<0.001); the levels of TNF in group B were significantly higher than those in group A (P<0.05); the levels of ET were increased, but there was no statistical significance. significance. Tip: Increased release of TNF and ET is important for the pathogenesis of MODS; further increases in TNF and ET release (especially TNF) may lead to more organ damage (including pancreatic function) and even failure.