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促炎细胞因子在许多病理状态下,如炎症、神经系统损伤、癌症等,对疼痛和痛觉过敏的发生和维持有重要作用。目前得到普遍认可的促炎细胞因子有IL-1β、IL-6、TNF-α,该文就IL-1β在炎性疼痛中的作用及其可能的外周、中枢机制作一综述。
Pro-inflammatory cytokines play an important role in the occurrence and maintenance of pain and hyperalgesia in many pathological conditions, such as inflammation, nervous system damage and cancer. The currently recognized pro-inflammatory cytokines are IL-1β, IL-6 and TNF-α. This review summarizes the role of IL-1β in inflammatory pain and its possible peripheral and central mechanisms.