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维A酸凝胶是我国1994年批准进口的一种药物,与迪维霜一样,临床上常用于治疗痤疮、牛皮癣等皮肤病。维A酸(tretinoin)性质不稳定,有文献报道了有关维A酸溶液和皮肤制剂的稳定性,但没有维A酸与其分解产物的色谱分离的报道。本文报告了一种快速、准确、灵敏的方法,可将维A酸与其分解产物完全分离,对于保证制剂质量、考察制剂稳定性,提供了一个有效的检测手段。
Vitamin A acid gel is a drug approved for import in 1994 in our country. Like Dive cream, it is clinically used to treat skin diseases such as acne and psoriasis. The nature of tretinoin is not stable. The stability of tretinoin and dermatological preparations has been reported in the literature, but no chromatographic separation of tretinoin and its decomposition products has been reported. This article reports a rapid, accurate and sensitive method for the complete separation of retinoids from their breakdown products, providing an effective means of assaying the quality of formulations and investigating formulation stability.