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目的探讨注射用培美曲塞二钠与注射用奈达铂二线治疗肺大细胞癌患者的临床疗效。方法选取2012年10月至2014年12月沈阳医学院附属中心医院收治的肺大细胞癌患者资料24例,给予注射用培美曲塞二钠与注射用奈达铂,分析其临床疗效、不良反应发生情况、生命质量改善情况和随访结果。结果 24例患者中,总有效率为33.3%(8/24),疾病控制率为70.8%(17/24),生命质量总改善率为87.5%(21/24);患者出现的主要不良反应为血红蛋白下降、白细胞计数下降、血小板计数下降。结论采用注射用培美曲塞二钠联合注射用奈达铂二线方法治疗肺大细胞癌临床疗效明显,可改善患者预后。
Objective To investigate the clinical efficacy of pemetrexed disodium injection and second-line injection of nedaplatin in the treatment of patients with pulmonary large cell carcinoma. Methods Twenty-four patients with large cell lung cancer admitted from the Central Hospital of Shenyang Medical College from October 2012 to December 2014 were enrolled, and received pemetrexed disodium injection and nedaplatin for injection. The clinical efficacy, Response, quality of life improvement and follow-up results. Results Among the 24 patients, the total effective rate was 33.3% (8/24), the disease control rate was 70.8% (17/24), and the total quality of life improvement rate was 87.5% (21/24). The major adverse reactions For hemoglobin decreased, white blood cell count decreased, decreased platelet count. Conclusion The injection of pemetrexed disodium injection combined with nedaplatin second-line treatment of pulmonary large cell carcinoma of the clinical efficacy is obvious, can improve the prognosis of patients.