论文部分内容阅读
目的:研究胡椒碱的抗抑郁作用,并对其作用机理进行初步探讨。方法:利用小鼠开野实验、强迫游泳实验和悬尾实验考察胡椒碱的抗抑郁作用,并通过测定小鼠脑内单胺类神经递质含量,探讨其作用机制。结果:胡椒碱给药1周后,能明显缩短小鼠在行为学实验中的不动状态时间。能显著提高脑内5-羟色胺水平,而对脑内去甲肾上腺素递质水平未见明显影响。结论:胡椒碱具有较好的抗抑郁作用,其作用是通过上调中枢神经系统5-羟色胺水平实现的。
Objective: To study the antidepressant effects of piperine and its mechanism of action. Methods: The antidepressant effect of piperine was investigated by open-field test, forced swimming test and tail-suspending test in mice. The mechanism of action was investigated by measuring the content of monoamine neurotransmitters in the brain of mice. Results: Piperine administration for 1 week significantly shortened immobility time of mice in behavioral experiments. Can significantly increase brain serotonin levels, and no significant effect on brain norepinephrine neurotransmitter levels. Conclusion: Piperine has a good antidepressant effect, and its effect is through the elevation of the central nervous system serotonin levels.