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目的 探讨支气管哮喘患儿红细胞免疫粘附功能的变化及糖皮质激素对哮喘患儿红细胞免疫粘附功能的影响。方法 采用酵母菌花环法对 42例支气管哮喘患儿 ,2 8例哮喘缓解期患儿及 2 0例健康儿童进行红细胞C3b受体花环率 (RBC -C3breceptorrosetterate,RBC -C3bRR)及红细胞免疫复合物花环率 (RBC -Immuno complexrosseterate,RBC -ICR)检测 ,同时检测 2 8例哮喘患儿缓解期应用激素吸入治疗 1月及 6月后的RBC -C3bRR及RBC -ICR。结果 哮喘发作组RBC -C3bRR较缓解组和对照组均明显下降 (P <0 0 5 ,P <0 0 1)。RBC -ICR较对照组升高 (P <0 0 5 )。哮喘患儿缓解期应用激素吸入治疗 1月后 ,RBC -C3bRR较未用药组高 ,差异有显著意义 (P <0 0 5 )。两组RBC -ICR差异无显著性 (P >0 0 5 )。激素治疗 6月后 ,RBC -C3bRR较未用药组明显升高 ,差异有高度显著性 (P <0 0 1)。两组RBC -ICR差异无显著意义 (P >0 0 5 )。结论 支气管哮喘患儿红细胞免疫粘附功能下降。缓解期激素吸入治疗可改善红细胞的免疫粘附功能
Objective To investigate the changes of erythrocyte immune adhering function in children with bronchial asthma and the effects of glucocorticoids on erythrocyte immune adhering function in asthmatic children. METHODS: Forty-two children with bronchial asthma, 28 children with asthma at remission and 20 healthy children were enrolled in this study. The rosette C3b receptor rosette rate (RBC-C3bRRR) and erythrocyte immune complex rosette (RBC-Immuno complexrosseterate, RBC-ICR), and RBC-ICRR and RBC-ICR were measured in 28 children with asthma at 1 and 6 months after remission. Results The RBC-C3bRR in asthma attack group was significantly lower than that in remission group and control group (P <0.05, P <0.01). RBC-ICR increased compared with the control group (P <0 05). The level of RBC-C3bRR in asthmatic children after remission was higher than that of the non-medication group at 1 month after remission (P <0.05). There was no significant difference in RBC-ICR between the two groups (P> 0.05). After 6 months of hormone therapy, the RBC-C3bRR was significantly higher than that of the untreated group, with a significant difference (P <0.01). There was no significant difference between the two groups in RBC-ICR (P> 0.05). Conclusion The erythrocyte immune function in children with bronchial asthma is decreased. Hormone remission therapy can improve the immune function of red blood cells