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目的:探讨不同的透皮吸收促进剂对玄丹巴布剂中淫羊藿苷体外透皮吸收作用的影响,筛选出有效的透皮吸收促进剂,以提高玄丹巴布剂的疗效。方法:采用正交试验法,以淫羊藿苷的透过率为评价指标考察了氮酮、丙二醇、薄荷脑3个因素对玄丹巴布剂透皮吸收影响。结果:薄荷脑用量为2%,氮酮用量为3%时,淫羊藿苷透皮吸收率最高,促透效果最明显,而丙二醇对淫羊藿苷透皮率影响较小。结论:氮酮、薄荷脑可提高玄丹巴布剂淫羊藿苷体外透皮吸收量。
Objective: To investigate the effect of different transdermal absorption accelerators on the transdermal absorption of icariin in Xundan poultice, and to screen out effective transdermal absorption enhancers to improve the efficacy of Xuan dan poultice. Methods: The effects of Azone, Propylene Glycol and Menthol on transdermal absorption of Hyanta cataplasm were studied by orthogonal test and Icariin transmission rate as evaluation index. Results: When the dose of menthol was 2% and the dose of azone was 3%, the transdermal absorption rate of icariin was the highest, and the penetration enhancement effect was the most obvious. Propylene glycol had little effect on icaritin permeability. Conclusion: Azone and menthol can increase the transdermal absorbability of Xiongdan cataplasma Icariin in vitro.