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目的：研究利多卡因唾液浓度（Ｃｓ）与血浆浓度（Ｃｐ）相关性。方法：１０例健康志愿者（男性３人，女性７人）单次ｉｖ盐酸利多卡因（１ｍｇ／ｋｇ）后３０，６０，９０ｍｉｎ分别同时采取唾液及血液标本，用荧光偏振免疫分析法（ＴＤｘ）测定利多卡因浓度。结果：利多卡因唾液浓度与血浆浓度的相关性：（１）３０ｍｉｎ时Ｃｓ与Ｃｐ相关性不显著；（２）６０ｍｉｎ时，Ｃｓ＝０．４０３７＋０．９１９６Ｃｐ，ｒ＝０．６６３２Ｐ＜０．０５，Ｃｓ与Ｃｐ呈正相关；（３）９０ｍｉｎ时，Ｃｓ＝－０．２１６２＋１．５２９９Ｃｐ，ｒ＝０．９０６３，Ｐ＜０．０１Ｃｓ与Ｃｐ呈显著正相关。Ｃｓ／Ｃｐ比值Ｒ＝１．４６７±ｓ０．７０６（ｎ＝３０）。结论：当利多卡因血浆浓度为０．２７ｍｇ／Ｌ～０．９１ｍｇ／Ｌ时，其Ｃｓ与Ｃｐ呈正相关。利多卡因唾液浓度为血浆浓度的１．５倍。
Objective: To study the correlation between lidocaine saliva concentration (Cs) and plasma concentration (Cp). Methods: Saliva and blood samples were taken simultaneously from 30 healthy volunteers (3 males and 7 females) at 30, 60 and 90 minutes after a single intravenous injection of lidocaine hydrochloride (1 mg / kg). Fluorescence polarization immunoassay (TDx ) To determine the lidocaine concentration. Results: The correlation between saliva concentration and plasma concentration of lidocaine: (1) The correlation between Cs and Cp was not significant at 30min; (2) Cs = 0.4037 + 0.9196Cp at 60min, r = 0.6632P <0.05 , Cs and Cp were positively correlated; (3) At 90min, Cs = -0.2162 + 1.5299Cp, r = 0.9063, P <0.01Cs had a significant positive correlation with Cp. Cs / Cp ratio R = 1.467 ± s0.706 (n = 30). CONCLUSIONS: When lidocaine plasma concentration is 0.27mg / L ~ 0.91mg / L, Cs has a positive correlation with Cp. Lidocaine saliva concentration of 1.5 times the plasma concentration.