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目的探讨结肠软斑病的临床病理特征、诊断与鉴别诊断及治疗与预后。方法分析1例结肠软斑病的临床表现及病理学特征,并复习相关文献。结果本例临床表现及肠镜结果疑为结肠癌,活检组织检查见大片组织细胞样细胞,细胞质丰富,局部细胞内外可见特征性呈靶环状或枭眼样的Michaelis-Gutmann小体,PAS和普鲁士蓝铁染色(+)。免疫组化:组织细胞样细胞CD68和CD163弥漫(+)。结论结肠软斑病比较少见,依据临床表现及肠镜结果容易误诊为肿瘤,熟悉并掌握其病理特征是诊断的关键。
Objective To investigate the clinical and pathological features, diagnosis and differential diagnosis, treatment and prognosis of the soft stain of the colon. Methods The clinical manifestations and pathological features of 1 case of condyloma acuminatum were analyzed and the related literatures were reviewed. Results The clinical manifestations and colonoscopy findings were suspicious of colon cancer. Biopsy tissue examination revealed a large number of tissue-like cells with rich cytoplasm. The inner and outer cells were characterized by Michaelis-Gutmann bodies with target ring or owl-like features. PAS and Prussian blue iron staining (+). Immunohistochemistry: Tissue-like cells diffuse with CD68 and CD163 (+). Conclusions Colon scleroderma is relatively rare. According to clinical manifestations and colonoscopy results, it is easy to misdiagnose as a tumor. Familiarity with and mastery of the pathological features is the key to diagnosis.