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硬皮病是以局限性或弥漫性皮肤及内脏器官结缔组织的纤维化或硬化,最后发生萎缩为特点的疾病,其原因未明,近代关于硬皮病的发病机制有如下一些学说。发病机制1.胶原代谢异常:众所周知,硬皮病属于结缔组织病,病变所在是结缔组织。从光学显微镜对皮肤及其累及器官的观察,认为乃胶原过度增生所致。电子显微镜的观察亦看到有细的胶原纤维增生。用硬皮病患者的纤维母细胞作人工培养,亦看到其胶原合成能力增强,比正常皮肤的纤维母细胞强4倍以上。在某
Scleroderma is a disease characterized by focal or diffuse fibrosis or sclerosis of the connective tissue of the skin and visceral organs and finally atrophy. The reason for this is unclear. There are some theories about the pathogenesis of scleroderma in modern times. Pathogenesis 1. Abnormal collagen metabolism: As we all know, scleroderma belongs to connective tissue disease, the lesion is connective tissue. From the optical microscope on the skin and its organs involved in the observation, that is due to collagen hyperplasia. Electron microscopy also saw the fine collagen fibers hyperplasia. Fibroblasts in patients with scleroderma for artificial cultivation, also saw its ability to enhance collagen synthesis, more than 4 times stronger than normal skin fibroblasts. In a