论文部分内容阅读
[目的]研究 p53蛋白表达在胃癌预后中的意义。[方法]采用免疫组织化学LSAB法 ,对152例胃癌组织中 p53蛋白表达进行检测 ,分析 p53表达与临床病理因素及预后之间的关系。[结果]p53蛋白表达阳性率为24 3%(37/152) ,其表达与胃癌各临床病理因素之间无明显相关性。p53表达在肠型胃癌与弥漫型胃癌之间不同 ,生存率分析显示 ,p53表达的不良预后者仅见于弥漫型胃癌而非肠型胃癌。[结论]p53蛋白表达可用于识别弥漫型胃癌中具侵袭性并伴不良预后的亚组胃癌病例
[Objective] To study the significance of p53 protein expression in the prognosis of gastric cancer. [Methods] Immunohistochemical LSAB method was used to detect the expression of p53 protein in 152 gastric cancer tissues. The relationship between p53 expression, clinicopathological factors and prognosis was analyzed. [Results] The positive rate of p53 protein expression was 24 3% (37/152). There was no significant correlation between the expression of p53 protein and clinicopathological factors of gastric cancer. P53 expression differs between intestinal type gastric cancer and diffuse type gastric cancer. The survival rate analysis showed that the poor prognosis of p53 expression was only found in diffuse gastric cancer but not in intestinal type gastric cancer. [Conclusion] p53 protein expression can be used to identify subgroups of gastric cancer cases with invasive and poor prognosis in diffuse gastric cancer