近查“制剂手册”(北京市卫生局编,1978)250页四环素片处方中含有碳酸钙,我认为不妥,因为:(1)四环素族能与多价阳离子如 Mg~(2+)、Ca~(2+)、Al~(3+)等起络合作用,含有这些离子的药物可影响四环素族的吸收。(2)碳酸钙又是抗酸药,能降低胃中酸度,使未被络合的四环素也不易吸收。(3)碳酸钙在口服片中多用以减 Recent investigation “preparation manual” (Beijing Municipal Health Bureau, ed., 1978) 250 tetracycline prescription contains calcium carbonate, I think it is inappropriate, because: (1) tetracycline family with multivalent cations such as Mg ~ (2+ ), Ca ~ (2 +), Al ~ (3 +) and so on. The drugs containing these ions can affect the tetracycline absorption. (2) calcium carbonate is antacid, can reduce the acidity in the stomach, tetracycline is not easily absorbed. (3) Calcium carbonate in the oral tablets and more to reduce