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目的分析脂肪乳注射液致药物不良反应(ADR)发生的特点。方法搜集我院1997-2009年应用脂肪乳发生不良反应病例,对其临床表现及实验室检查资料进行回顾性分析。结果共发现发生脂肪乳ADR36例。临床表现多数为过敏反应(75%),甚至过敏性休克(11.1%),另外包括中枢神经系统不良反应(22.2%)以及肾功能损害(3.1%)。结论临床使用脂肪乳注射液时应全面考虑患者综合状况,重视脂肪乳使用的安全性问题。
Objective To analyze the characteristics of adverse drug reaction (ADR) induced by fat emulsion injection. Methods Collecting cases of adverse reactions of fat emulsion in our hospital from 1997 to 2009 were retrospectively analyzed on the clinical manifestations and laboratory examination data. Results A total of 36 cases of ADR occurred in fat emulsion. The majority of clinical manifestations were anaphylactic reaction (75%) and even anaphylactic shock (11.1%). Other adverse events (22.2%) were central nervous system and renal dysfunction (3.1%). Conclusion The clinical application of fat emulsion injection should fully consider the comprehensive status of patients and pay attention to the safety of the use of fat emulsion.