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目的探讨β2-微球蛋白(β2-MG)和胱抑素C(Cys C)联合检测与艾滋病(AIDS)并发早期肾损伤的诊断价值。方法选取191例艾滋病患者和191例健康体检者,检测其β2-MG、Cys C、肌酐(Cr)和尿素氮(BUN)水平并行统计学分析。结果 HIV组和对照组比较,β2-MG、Cys C、Cr、BUN差异有统计学意义(P<0.05)。HIV组β2-MG、Cys C和β2-MG加Cys C联合阳性率明显高于对照组(P<0.05)。艾滋病期、感染中期、原发感染期β2-MG与Cys C呈正相关(r=0.763、0.565、0.568,P<0.05)。结论β2-MG、Cys C水平升高与肾脏早期损伤关系密切,联合检测对辅助诊断AIDS患者早期肾损伤及监测其病情发展具有重要的临床参考价值。
Objective To investigate the diagnostic value of combined detection of β2-microglobulin (β2-MG) and cystatin C (Cys C) and AIDS with early renal injury. Methods A total of 191 HIV / AIDS patients and 191 healthy controls were enrolled. The levels of β2-MG, Cys C, creatinine (Cr) and blood urea nitrogen (BUN) were measured and statistically analyzed. Results The difference of β2-MG, Cys C, Cr and BUN between HIV group and control group was statistically significant (P <0.05). The positive rates of β2-MG, Cys C and β2-MG plus Cys C in HIV group were significantly higher than those in control group (P <0.05). During the AIDS stage and the middle stage of infection, there was a positive correlation between β2-MG and Cys C in primary infection (r = 0.763, 0.565, 0.568, P <0.05). Conclusions The elevated levels of β2-MG and Cys C are closely related to the early renal damage. Joint detection is of great clinical value in the diagnosis of early renal injury and monitoring the progression of AIDS in AIDS patients.