论文部分内容阅读
整合素家族是一类由一个α亚单位和一个β亚单位通过非共价键连接而成的异二聚体跨膜糖蛋白。整合素β1亚家族是整合素家族中最重要的一类。在正常肝脏中某些不表达或低表达的整合素β1亚家族,在肝癌中高表达,从而介导细胞与细胞外基质(ECM)的粘附,接受并传导级联信号以调节肝癌细胞存活、凋亡、粘附运动等,在肝癌的粘附、转移中起着重要作用。
The integrin family is a class of heterodimeric transmembrane glycoproteins that are non-covalently linked by an alpha subunit and a beta subunit. The integrin β1 subfamily is the most important class of integrin families. Some non-expressed or underexpressed integrin β1 subfamilies in normal liver are highly expressed in hepatocellular carcinoma, which mediate cell adhesion to extracellular matrix (ECM), accept and transmit cascade signals to regulate the survival of hepatoma cells, Apoptosis, adhesion movement, etc., play an important role in the adhesion and metastasis of liver cancer.