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目的是探讨肺癌患者化疗中不同的用药方式的副作用以及临床疗效的评价。方法选取2010年1月至2011年1月本医院的50名住院接受EP(顺铂,依托泊苷)方案化疗前四个疗程的肺小细胞癌患者,进行回顾性分析EP方案中顺铂的不同用药途径在肺癌(SCLC)治疗中的近期疗效和不良反应。结果 1次组和分次组近期有效率分别68%和72%,两组比较差异无统计学意义(P>0.05);1次组不良反应(乏力、食欲减退、恶心、呕吐、脱发、口腔溃疡及发热)发生率均明显高于分次组(P<0.05)。结论分次组明显改善肺癌化疗患者的睡眠质量及化疗不良反应发生情况,使患者的生活质量得到明显提高,顺铂分次用药能减轻化疗相关毒副作用,提高患者的生活质量。
The purpose is to investigate the side effects of different modes of chemotherapy in patients with lung cancer chemotherapy and evaluation of clinical efficacy. Methods From January 2010 to January 2011, 50 hospitalized patients with small cell lung cancer who received the first four courses of chemotherapy for EP (cisplatin and etoposide) were enrolled in this study. The clinical data of patients with cisplatin Short-term efficacy and side effects of different routes of administration in the treatment of lung cancer (SCLC). Results The effective rates of the first and the second subgroups were 68% and 72% respectively, with no significant difference between the two groups (P> 0.05). The adverse reactions of the first group (fatigue, loss of appetite, nausea, vomiting, Ulcer and fever) were significantly higher than the graded group (P <0.05). Conclusion Divided group significantly improved the quality of sleep and adverse reactions of chemotherapy in patients with lung cancer chemotherapy, so that the quality of life of patients was significantly improved, cisplatin medication can reduce chemotherapy-related side effects and improve the quality of life of patients.