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白细胞介素－６是免疫应答及炎症反应的细胞因子网络中的关键成分，与肾脏疾病的关系也最为密切。已发现白细胞介素－６可由肾小球系膜细胞生成，并参与肾小球疾病的发生、发展。本文评述了白细胞介素－６的生物学特性，阐明其在ＩｇＡ肾病发病机理中的作用和临床应用价值。
Interleukin-6 is a key component of the cytokine network of immune responses and inflammatory responses and is most closely related to kidney disease. Interleukin-6 has been found to be produced by mesangial cells and involved in the development and progression of glomerular diseases. This article reviews the biological characteristics of interleukin-6 and clarifies its role in the pathogenesis of IgA nephropathy and its clinical value.