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目的了解开封市儿童医院手足口病区抗菌药物的使用原因,对抗菌药物对部分手足口病患儿的治疗意义进行研究,探讨抗菌药物科学管理依据。方法通过查阅病历,收集手足口病历250份,以入院后第1天血常规检查白细胞计数及中性粒细胞比例正常接受常规治疗者为空白组,血常规检查白细胞计数及中性粒细胞比例升高接受常规治疗者为对照组,血常规检查白细胞计数及中性粒细胞比例升高除接受常规治疗外使用抗菌药物治疗者为观察组,对三组患儿入院第1天白细胞计数及中性粒细胞比例、出院前白细胞计数及中性粒细胞比例、最后转归情况、住院天数进行统计学分析。结果手足口病入院第1天三组患儿白细胞计数及中性粒细胞比例差异有统计学意义,对照组和观察组均高于空白组(P<0.05),对照组和观察组之间比较差异无统计学意义(P>0.05);入院治疗3 d后三组患儿白细胞计数及中性粒细胞比例之间比较差异无统计学意义(P>0.05);三组患儿住院天数比较差异无统计学意义(P>0.05);三组患儿最终转归情况差异无统计学意义(P>0.05)。结论白细胞计数及中性粒细胞比例升高不是合并细菌感染的指征,抗菌药物使用无意义,应严格控制。
Objective To investigate the use of antibacterials in hand, foot and mouth area of Kaifeng Children’s Hospital, and to study the therapeutic significance of antibacterials on children with hand-foot-mouth disease and to explore the scientific basis for the management of antibacterials. Methods The medical records were collected and 250 cases of hand, foot and mouth were collected. On the first day after admission, the white blood cell count and the neutrophil proportion were routinely accepted as the blank control group. The blood test was used to detect the white blood cell count and neutrophil ratio High accepted routine treatment for the control group, blood routine examination of white blood cell count and neutrophil increased in addition to conventional treatment with antimicrobial therapy for the observation group, three groups of children admitted to hospital on the first day of white blood cell count and neutral Granulocyte ratio, pre-discharge white blood cell count and neutrophil ratio, the final outcome of the case, the number of hospital days for statistical analysis. Results The difference of the white blood cell count and the neutrophil ratio of the three groups on the first day after hand-foot-mouth disease admitted to hospital was statistically significant (P <0.05), compared with the control group and the observation group There was no significant difference between the three groups (P> 0.05). There was no significant difference in leucocyte count and neutrophil ratio between the three groups (P> 0.05) There was no statistical significance (P> 0.05). There was no significant difference in final outcome between the three groups (P> 0.05). Conclusions Leukocyte count and neutrophil ratio increase are not indications of bacterial infection. Antimicrobial drugs are useless and should be strictly controlled.