Objective: To examine the therapeutic mechanism of Yuxingeng liquid (愈心梗液,YXGL)on early ventricular remodeling in Wistar rats with acute myocardial infarction(AMI). Methods: Measuring the cardiac index (CI), left ventricular weight (LVW) and cardiac myocyte dimension and observing the concentration of endothelin (ET) and angiotensin Ⅱ (Ang Ⅱ ) in the plasma and myocardium. AMI models were established by ligature of left anterior descending coronary artery and the rats with AMI were randomly divided into 6 groups: the model group, sham-operation group, captopril group, high dosage YXGL group, middle dosage YXGL group and low dosage YXGL group. From the next day after modeling, the rats had been given YXGL through the gastric tube, which lasted for 4 weeks. And then, CI,LVW and concentration of ET and Ang Ⅱ in the plasma and myocardium were tested. Results: Comparing with model control group, high dosage YXGL, middle dosage YXGL and captopril can all significantly reduce CI, LVW, cardiac cell dimension and content of ET and Ang Ⅱ in both plasma and myocardium (P＜0. 05 or P＜0.01). Conclusion: YXGL can remarkably reduce LVW, CI and concentration of ET and Ang H, and lowering the concentration of ET and Ang Ⅱ is possibly one of the mechanisms intervening the pathological course of the early ventricular remodeling in rats with AMI.