干扰素(Interferons,IFNs)是现今公认的首要细胞素(Cytokine)。IFNs的研究范围很广,主要包括临床干扰素学、干扰素分子生物学、干扰素遗传学、干扰素生物化学、干扰素免疫学和干扰素生物学等。IFNs的临床效用是它的“生命”。就临床干扰素学而言,其历史、现状和未来,可作如下概括和评述。 1 辉煌的历史 IFNs以重组先锋的角色进入基因工程时代。在本世纪70年代后半期至80年代前半期IFNs的这段研究历史,给世人留下了极为深刻的印象。其研究声势之浩荡,规模之宏大和投资之巨甚,在生命科学史和医学科学史上都是很罕见的。当时,几乎整个生命科学界和医学科学界都投入了IFNs的研究。美国Slonketline癌症研究中心每月向世界各有关研究单位投发《干扰素研究通讯》以及时沟通信息,各新闻媒介单位的触角时时伸展搜寻,竞相传播“干扰素快讯”。全世界有几十个国家开展 Interferons (IFNs) are now recognized as the first cytokines (Cytokines). The study of IFNs is very broad, including clinical interferon, interferon molecular biology, interferon genetics, interferon biochemistry, interferon immunology and interferon biology. The clinical utility of IFNs is its “life.” As far as clinical interferonology is concerned, its history, current status and future can be summarized and reviewed as follows. A glorious history of IFNs in the role of restructuring pioneer into the era of genetic engineering. The history of this study of IFNs from the late 1970s to the first half of the 1980s left a deep impression on the world. Its research is full of momentum, huge scale and enormous investment, both in the history of life science and medical science are very rare. At that time, almost all life sciences and medical sciences were involved in the study of IFNs. The Slonketline Cancer Research Center of the United States issues “Interferon Research Letters” to the relevant research institutes in the world on a monthly basis to timely communicate information. All news media units have been constantly searching for and spreading “interferon newsletters”. Dozens of countries around the world carry out