目的:米索前列醇配伍利凡诺羊膜腔注射治疗妊娠中期引产与对照组对比的效果。方法:观察组采用利凡诺羊膜腔穿刺术后18小时～22小时给予米索前列醇肛门上药,对照组只采用利凡诺羊膜腔穿刺术后观察待产。结果:观察组有效率100%,完全流产率94.7%。对照组有效率为97%,不完全流产率为41%。结论:米索前列醇配伍利凡诺羊膜穿刺治疗妊娠中期引产,更能有效软化宫颈,促进宫缩,完全流率高,减少宫腔操作,是较安全终止中期妊娠方法。 Objective: Misoprostol compatibility rivanol amniotic cavity injection in the second trimester induction of labor compared with the control group. Methods: The patients in the observation group were treated with misoprostol on the anus for 18 hours to 22 hours after rivanol amniocentesis. The control group was treated with rivanol amniocentesis for observation. Results: The observation group was 100% effective and the complete abortion rate was 94.7%. In the control group, the effective rate was 97% and the incomplete abortion rate was 41%. Conclusion: Misoprostol combined with Rivinol amniocentesis in the second trimester induction of labor, more effective in softening the cervix and promote uterine contractions, complete high flow rate and reduce uterine cavity operation, is a safer termination of midterm pregnancy.